In conclusion, the present study indicates that growth hormone de-ficiency is associated with an increased risk of atherosclerosis in children.
Positive effects of rhGH administration on the lipid profile and
CIMT of the subjects was confirmed after 1 year of treatment. However,long-term studies of a greater number of GHD children are needed to
understand the exact mechanism underlying the effect of growth and
the IGF-1 axis on the vascular endothelium.