an hypothesis first put forward 50 years ago
Introduction
Diabetes is currently estimated to affect 382 million people worldwide [1], with severe consequences for the health and economy of developed and developing nations alike. Type 2 diabetes (T2D) is thought to originate from an interplay between genetic and lifestyle factors, an hypothesis first put forward 50 years ago [2]. Lifestyle interventions can reduce the risk of progression to diabetes in high-risk individuals by 50% or more [3]–[6]; however, whether the consequences of adverse lifestyles differ according to the underlying genetic susceptibility to T2D remains uncertain.