In this scenario, the crosspollination between biotechnology,nanoscience, nanotechnology, pharmaceutics and biomedicine is shifting the attention to bioinspired and/or bioengineered nanocar-riers [6]. Nanoparticles derived from natural macromoleculesself-assembly are considered extremely promising. Among thevarious bio-building blocks, self-assembling proteins have uniquefeatures as they can form supramolecular structures giving riseto symmetrical nano-objects [7]. These so called ‘protein cages’can be made of ferritin-like proteins, chaperons, heat shock pro-teins and, most notably, viral proteins [8,9]. The majority of virusnanoparticles (VNPs) display a spherical or a rod shape, and can besurprisingly diverse in terms of symmetries, dimensions and struc-ture related properties. Additional intriguing features include theinherent monodispersity and extreme flexibility in terms of engi-neering strategies, the latter allowing the effective modification ofthe exposed surfaces and/or the exploitation of the internal cav-ity for cargo storage. For these reasons, VNPs have been proposedsince the dawn of nanotechnology as carriers for targeted drugdelivery, vaccinology, and imaging [10]. In this context, plant VNPs(pVNPs) are attracting increasing attention. Several plant viruseshave been exploited for biomedical applications and successfullytested in animal models [11]. Plants, such as the Solanacea Nicotianabenthamiana L., relative of common tobacco, allow a convenientand easily scalable production of pVNPs that, when outside theirspecific plant host, become protein nanoshells unable to replicate.