Dengue virus (DV†) is one of the most important vector-borne diseases in the world. It
causes a disease that manifests as a spectrum of clinical symptoms, including dengue hemorrhagic
fever. DV is proficient at diverting the immune system to facilitate transmission
through its vector host, Aedes spp. mosquito. Similar to other vector-borne parasites,
dengue may also require a second structural form, a virus of alternative morphology (VAM),
to complete its life cycle. DV can replicate to high copy numbers in patient plasma, but no
classical viral particles can be detected by ultra-structural microscopy analysis. A VAM appearing
as a microparticle has been recapitulated with in vitro cell lines Meg01 and K562,
close relatives to the cells harboring dengue virus in vivo. VAMs are likely to contribute to
the high viremia levels observed in dengue patients. This review discusses the possible existence
of a VAM in the DV life cycle.
Dengue virus (DV†) is one of the most important vector-borne diseases in the world. Itcauses a disease that manifests as a spectrum of clinical symptoms, including dengue hemorrhagicfever. DV is proficient at diverting the immune system to facilitate transmissionthrough its vector host, Aedes spp. mosquito. Similar to other vector-borne parasites,dengue may also require a second structural form, a virus of alternative morphology (VAM),to complete its life cycle. DV can replicate to high copy numbers in patient plasma, but noclassical viral particles can be detected by ultra-structural microscopy analysis. A VAM appearingas a microparticle has been recapitulated with in vitro cell lines Meg01 and K562,close relatives to the cells harboring dengue virus in vivo. VAMs are likely to contribute tothe high viremia levels observed in dengue patients. This review discusses the possible existenceof a VAM in the DV life cycle.
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