Subjects were classified into four groups according tomaternal age at delivery: 20e29 years, 30e34 years, 35e39years, and 40 years. The group of women aged 20e29 yearswas used as the reference group for all comparisons. In Korea,the proportion of women delivering at age 30e34 years is thehighest in all age groups, therefore, we divided our populationin that way. The demographic information consisted ofgravidity, parity, history of spontaneous abortion, body massindex (BMI), history of in vitro fertilization (IVF) use incurrent pregnancy, and history of pre-existing medical conditionsincluding chronic hypertension, pregestational diabetes,cardiac disease, thyroid disease, epilepsy, and asthma. TheBMI calculated before 18 completed weeks of gestation attheir first visit was used.Perinatal and obstetric outcomes were analyzed. Perinataloutcomes included preterm delivery (<37 weeks of gestation),very preterm delivery (<32 weeks of gestation), extremelypreterm delivery (<28 weeks of gestation), low birth weight(<2.5 kg), very low birth weight (<1.5 kg), extremely lowbirth weight (<1 kg), macrosomia (birth weight > 4 kg), smallfor gestational age (SGA; < 10th percentile of birth weight forgestational age) [11], large for gestational age (LGA; > 90thpercentile of birth weight for gestational age) [11], chromosomalanomaly, congenital structural anomaly including majorand minor anomaly without any confirmed chromosomalanomaly, miscarriage (fetal loss after enrollment but before200/7 weeks), and perinatal loss (intrauterine death after 196/7weeks gestation and neonatal death within 28 days of birth).Obstetric outcomes consisted of antepartum complicationsand delivery mode. Antepartum complications were composedof hypertensive disorders complicating pregnancy (HTN)including gestational hypertension, preeclampsia, eclampsia,and superimposed hypertension); GDM; and preterm prematurerupture of membranes (PPROM: membrane rupturebefore 37 weeks of gestation). Lastly, mode of delivery wasclassified as vaginal delivery or cesarean delivery, and indicationsfor primary cesarean section involved arrest disorder,induction failure, placenta previa, and previous myomectomy.Differences in characteristics between groups wereassessed using the c2 test and one-way analysis of variance.Multivariable logistic regression analysis was used to evaluatethe associations between maternal age and dependent outcomevariables, namely to calculate the adjusted odd ratios (AORs)of pregnancy outcomes according to increasing maternal ageby controlling for confounding factors. Potential confoundingfactors included gravidity, parity, history of spontaneousabortion, BMI, history of IVF use, and history of pre-existingmedical conditions. AOR and 95% confidence intervals (CIs)were calculated. A p value < 0.05 was considered statisticallysignificant. Statistical analysis was performed using SPSSversion 12.0 (SPSS Inc., Chicago, IL, USA).
การแปล กรุณารอสักครู่..