Buffaloes are the major part of subsidiary economy to the rural people in costal Andhra Pradesh in India. However, buffaloes along with cattle are prone to the intramammary infections, and these have a lot of economic impact on the farmer. The present work was taken up with the objective to find out whether the risk factors influencing mastitis in cattle and buffaloes are the same or whether any additional risk factors play a role in buffalo mastitis. Further the study also focussed on whether normal, clinical and sub-clinical somatic cell counts in buffaloes are the same in buffaloes as in cattle.