The experimental mice
were randomly divided into seven groups: normal group,
virus group, model group, ribavirin group, edaravone group,
vitamin C-low dosage group, and vitamin C-high dosage
group. Model group mice were treated with restraint stress
plus virus infection. Ribavirin (60mg/kg) and vitamin C (125
or 250mg/kg) were administered to mice by oral gavage and
edaravone (3mg/kg) was administered to mice by intraperitoneal
injection for 7 consecutive days.The remaining groups
received oral administration and intraperitoneal injection
of water only. On the 1st day of administration, except for
normal and virus groups,mice were physically restrained in a
50mL polypropylene restraint tube with holes for 18 h. After
recovering for three days, except for normal group,mice were
anesthetized by inhalation of ether vapor and then an approximate