The keywords ‘toxicity* or adverse drug
reaction* or adverse event* or side effect* or adverse effect*’
were used as recommended by the BMC Medical Research
Methodology for systematic reviews of adverse effects.3
Additionally, the keyword ‘safety*’ was used as in a previous systematic
review.4 The terms recommended by search strategies
for MEDLINE were used to cover the paediatric age group
‘child* or children* or p*ediatric* or infant* or adolescent*’.5