A 22 full factorial study was conducted for spray drying with the following variables: RMD solution concentration and spray drying inlet temperatures. A total of four, 100 mL naringin (3% w/v) suspensions were prepared by slowly adding the polyphenol to a solution of RMD prepared in ultrapure water, accompanied by stirring with a magnetic bar at 1000 rpm for 20 min. The RMD solutions were prepared at two concentrations (20 and 40% w/v). Spray drying was conducted in an amber colored spray drying chamber since polyphenols are usually light sensitive (Fang and Bhandari, 2010) at temperatures of 155 and 180 °C using a nozzle of 0.7 mm diameter and constant feed flow rate of 3 mL/min. The full experimental design and assigned formulation codes in shown in Table 1. Only one trial was carried out per combination of RMD concentration and spray drying inlet temperature.