Distinct beneficial effects of fish (LC n-3 PUFA) consumption have been reported on insulin sensitivity, type 2 diabetes mellitus (T2DM), lipid profile, and risk for death from coronary heart diseases in healthy individuals [35–38] or of α-linolenic acid (ALA) intake on reduced risk of myocardial infarction [39]. Total n-3 PUFA supplies were also associated with higher levels of anti-inflammatory markers (soluble IL-6r, IL-10, TGFβ) in healthy adults [40]. Together, all those observations support that dietary n-3 PUFA may specifically influence the development of insulin resistance and progression of the MetS, and associated cardiovascular risk.