. Thus in a genomic area that contains multiple non-B DNA-forming sequences, one tract may form a specific non-B DNA conformation at a given time, and may inhibit or promote another form of non-B DNAatthe same or nearby tracts under given conditions. Moreover, DNA is in a dynamic state such that transitions between non-B and B-DNA may be on-going, where a transition from non-B to B-DNA in one tract may give rise to non-B formation in other regions. Until a direct and conclusive method is developed to detect a specific DNA structure within a region of multiple non-B DNA formingsequences, careful consideration is warranted when studying the biological effects of such a complex and dynamic region of the genome.
Conflict of interest stat