The principal aim of an active packaging solution is to control the package headspace composition during food storage. Controlled release packaging (CRP) is a new generation of packaging materials that can release active compounds at different controlled rates to enhance the quality and safety of a wide range of foods during storage. Different active substances with different mechanisms of action have been investigated and discussed in this chapter. The ultimate goal of an active packaging system should be the reduction of food loss and waste, extending product shelf life and reducing waste by clarifying the suitability of a product for consumption.