Many of andrographolide analogues indicating immunostimulatory properties (Chao & Lin 2010). Andrographolide was reported to have immunoregulatory activities with different effects in different immune disease models, playing a role as a modulator of altered immune responses. In tumorbearing mice it enhanced natural killer cell activity, increased secretion of IL-2 and IFN-γ by T cells and thereby inhibited the tumor growth. However, in autoimmune encephalomyelitis mice, it interfered maturation of dendritic cells, induced antigen-specific tolerance and thus prevented detrimental autoimmune responses (Wang et al. 2010). In vivo study using