The rules are derived from the literature and data analysis
based on the experimental study. Environmental conditions
are defined based on the relative concentration of selected
bioreactor variables (Bayrak et al., 2015). The abstracted rule
base is shown in Fig.3. Each CHO agent receives the
environmental conditions based on that and its state (i.e., cell
cycle phase) in the previous time step, then decides either to
go through the cell cycle or apoptosis path. During this step,
the cell also updates its parameter set governing its behavior.
Complete rule-base and parameters have been described
previously (Bayrak et al., 2015).