ApoE KO mice and its wild type mice were fed atherogenic diet containing either 10% lard(LD)orperilla oil (PE). In apoE KO group fed PE(APE), brain total cholesterol and trigrlyceride concentrations were reduced by 8 and 17%, respectively, than apoE KO group fed LD (ALD). Brain lipid peroxidation and NFkB expression of APE were inhibited by 20.83 and 60% compared to those for the ALD. Neuronal apoptos is of APE was significantly reduced by 37% than ALD group. These results suggest that PE would ameliorate the brain damage underhypercholesterolemia induced by atherogenic diet via inhibiting
the oxidatives tressand inflammation.