Our systematic review and meta-analysis had several
strengths. We used a broad search strategy that included peer-reviewed articles in addition to conference abstracts
presented at recent HIV conferences. We also contacted authors
to acquire additional data for some summary measures. Two
independent reviewers evaluated full-text articles for relevance
and abstraction of data. HIV incidence rates, cumulative HIV
incidence, and risk of HIV acquisition were pooled separately by
pregnancy and postpartum status, as well as together, to better
understand risks specific to pregnancy versus the postpartum
period. To complement the meta-analysis of HIV incidence, we
also pooled MTCT rates among mothers with incident infection,
and compared the risk of MTCT for women with incident versus
chronic infection.
Our systematic review and meta-analysis had severalstrengths. We used a broad search strategy that included peer-reviewed articles in addition to conference abstractspresented at recent HIV conferences. We also contacted authorsto acquire additional data for some summary measures. Twoindependent reviewers evaluated full-text articles for relevanceand abstraction of data. HIV incidence rates, cumulative HIVincidence, and risk of HIV acquisition were pooled separately bypregnancy and postpartum status, as well as together, to betterunderstand risks specific to pregnancy versus the postpartumperiod. To complement the meta-analysis of HIV incidence, wealso pooled MTCT rates among mothers with incident infection,and compared the risk of MTCT for women with incident versuschronic infection.
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