Novel approaches to leveraging whole genome and exome sequences in families (Cruchaga et al., 2014; Guerreiro et al., 2012; Kauwe et al., 2013), or careful identification of candidate genes from other diseases (Guerreiro et al., 2012) or biological work (Lu et al., 2014), will also facilitate identification of additional variants. Such work is vital to the development of therapeutics and each gene represents a potential target for development.