Resistance profile
Another advantage of dolutegravir relates to the barrier to
resistance. When analyzing those experiencing virologic
failure while on dolutegravir as first-line therapy, no resistance
mutations were discovered.68 This contrasts with the
four of 281 patients who developed raltegravir resistance in
STARTMRK at 5 years and one of 411 patients in SPRING-2
at 96 weeks.13,45 In comparison, at week 144, elvitegravirresistant