In this review, we summarize the evidence for the impact of HPV vaccination in reducing the prevalence of cervical As of this writing, there are three commercially available HPV vaccines based on virus-like particles of the L1 capsid protein. They are remarkably efficacious and safe Table 1 shows their characteristics and target population. Vaccine safety and efficacy have been confirmed in pre- and post-licensure studies and Fewer than the currently recommended three doses of HPV vaccines has been proven to be effective [15] and [16]. A switch from a three- to a two-dose schedule for primary immunization programmes is hence anticipated, especially in younger adolescents aged between 9 and 13 years [10]. Development and clinical validation of new HPV vaccines by pharmaceutical companies has continued. The next generation of vaccines may increase the range of protection against additional HR-HPV types, as well as to infections and associated diseases caused by mucosal and cutaneous HPV types alike, thus targeting most HPV types that can potentially cause benign or malignant diseases [17].