Inverse gas chromatography (IGC) represents a unique refinement of a classic chromatographic method has the
potential to unlock some of the more difficult to measure physicochemical properties of pharmaceutical
materials such as powder surface energies, acid/base/polar functionality of surfaces, diffusion kinetics, solubility
parameters, surface heterogeneity and phase transition temperatures/humidities. In IGC the roles of the
stationary (solid) and mobile (gas or vapor) phases are inverted from traditional analytical gas chromatography
(GC). In IGC, a single gas or vapor (probe molecule) is injected into a column packed with the solid sample under
investigation. Instead of an analytical techniqueIGC is considered a materials characterization technique