However, to possess wisdom and appreciate the meaning of life, it is not sufficient simply to know reality. You need to know what aspects of reality matter, and why they matter. Wisdom without knowledge is empty, but knowledge without wisdom is blind. The capacities of brains to gain knowledge by perception and inference to the best explanation are required for the acquisition of wisdom, but also required are capacities for assigning positive and negative values to what is represented, including aspects of love, work, and play. We can understand this more deeply by investigating how brains have emotions.