The production of pasta filata cheeses using a mixture of ewe or goat milk could be an interesting and feasible opportunity for the dairy industry of Southern Italy, allowing its expansion in the market. Regarding this opportunity, the development of appropriate technologies for the production of innovative and reformulated cheeses, aimed at obtaining products with proper characteristics and satisfactory acceptance by consumers, is of particular interest. The goal of this study was to develop innovative Caciocavallo cheeses made from a mixture of ewe or goat milk with cow milk. The achieved cheeses were assessed for their physicochemical, microbiological, and sensorial characteristics through a comparison with traditional Caciocavallo cheeses made from cow milk.