For these reason a series of advelopmen therefore we hypothesiz that increasing the adenosine concenin the brain may also prolong the cns-ot latency and fight hbo-induced cns-ot by administering the exogenous adenosine directly we found that the cns-ot latency duration extended with increasing dose of injected adenosine adk activity plays an important role in the tone of ambient adenosine adk inhibition is previously used as a therapeutic strategy to prevent epilepsy. Thus we selected 5-ditu an adk inhibitor infused intothe brain to increase the adenosine level indirectly reults showed that 5-ditu dose dependently delayed the cns-ot latency.