A Cox proportional hazard regression model was developed
to evaluate the association between the potential prognostic
markers and overall survival at multivariate level. The variables,
including miR-1246 expression, nodal status, TNM stage, tumor
grade, and local recurrence, were selected in the final multivariate
model because their Wald test p values were less than
the generally used criterion of 0.05. The results revealed that
miR-1246 expression (p=0.036; HR=2.82; 95% CI=1.07–7.43),
TNM stage (p=0.003; HR=2.97; 95% CI=1.46–6.05) and tumor
grade (p=0.006; HR=3.04; 95% CI=1.37–6.74) were independent
prognostic parameters for OSCC (Table 2).
A Cox proportional hazard regression model was developedto evaluate the association between the potential prognosticmarkers and overall survival at multivariate level. The variables,including miR-1246 expression, nodal status, TNM stage, tumorgrade, and local recurrence, were selected in the final multivariatemodel because their Wald test p values were less thanthe generally used criterion of 0.05. The results revealed thatmiR-1246 expression (p=0.036; HR=2.82; 95% CI=1.07–7.43),TNM stage (p=0.003; HR=2.97; 95% CI=1.46–6.05) and tumorgrade (p=0.006; HR=3.04; 95% CI=1.37–6.74) were independentprognostic parameters for OSCC (Table 2).
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