Normally, plants contain natural phenolic compounds which can produce antioxidant properties in vitro, though it is not guarantee that those plant extracts would exert useful therapeutic actions in vivo for several reasons. For example, the active ingredients may not be absorbed from the site of administration or enzymatic degradation may occur before reaching the target organ. However, the data from this study showed that D. reticulata extract produced anti-diabetic activity against alloxan induction in vivo. The extract signifi- cantly increased the body weights of diabetic rats com- pared to the diabetic control group. In accordance with the results on body weights, diabetic rats treated with D. reticulata extract showed significant decreases in blood glucose level similar to glibenclamide-treated group. The microscopic photograph from pancreatic hematoxylineosin staining demonstrated a destruction of the pancreatic islet cells, such as shrink and irregular shape, in diabetic control rats. The islet cells of the diabetic rats treated with D. reticulata extruct provides the evidence of less degeneration. An increase in the levels of hepatic enzymes, such as AST: ALT. glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transferase (GPT), has been established in diabetic rats i by toxic chemicals, including alloxan and streptozotocin [6,9]. In this study. alloxan-induced increase of AST and ALT were de- creased in rats administrated with D. reticulata extract compared to diabetic control group. In addition to pan- creas, the result suggested that the extract also exerted hepatoprotective activity.