Concord grape juice contains a variety of flavonoids and
antioxidants, among them anthocyanins and proanthocyanidins
(18,19) and comparatively high levels of total phenolics(20).
Information concerning flavonoid transport into the central
nervous system and absorption into brain tissue is emerging.
A number of recent studies have indicated that certain of
these compounds, in particular anthocyanins, cross the
blood–brain barrier, although specific mechanisms have not
been established(21 – 23). In addition, anthocyanins have been
identified in brain regions that mediate cognition, including
the medial temporal lobe and cortex(24), and hippocampal distribution
has been associated with behavioural enhancement in
animal supplementation studies(24