Morphology of cytoplasm in various types of AML. Cytoplasmic features are shown with standard Wright-Giemsa staining (left column), histochemistry (middle column), and CD45 versus side scatter by flow cytometry (right column) in various types of AML. Demonstrated here are: acute myelomonocytic leukemia with two distinct blast populations: acute monocytic leukemia with ample esterase+ cytoplasm, acute erythroid leukemia (pure erythroleukemia type shown here) with coarse PAS+ cytoplasmic granules, CD45 weak/negative blasts, and acute megakaryocytic leukemia with CD61+ blasts that are weakly CD45 positive. (Histograms courtesy J. Davidson and T. Anderson.)