Thiazolidinediones have also been reported to decrease urinary albumin excretion excretion to a greater extent then expected for the improvement in glycaemic control and to reduce circulating markers of chronic low-grade inflammayion. Preclinical studies suggesting that treatment of glucose-intolerant animals with a thiazolidinedione preserved bata cell function have yet to be confirmed in human studies. In insulin-resistant women with a history of gestational diabetes at high risk of type 2 diabetes trogliazone reduced the incidence of newonset diabetes.