In addition, we used another metastatic breast cancer
cell line (MDA-MB-453) to evaluate the combination effect on
apoptotic induction. Although MDA-MB-453 had a higher resistance
to paclitaxel, the combination of luteolin and paclitaxel significantly
enhanced the apoptotic cell population in MDA-MB-453
cells compared with paclitaxel (40 nM) alone (Fig. 2D)