The hydrogen atoms or the metal groups in the above
case are replaced by the poisoning metal and the
enzyme is thus inhibited from functioning, whereas the
protein–metal compound acts as a substrate and reacts
with a metabolic enzyme. In a scheme shown below
(equation C), enzymes (E) react with substrates (S) in
either the lock-and-key pattern or the induced-fit pattern.
In both cases, a substrate fits into an enzyme in a highly
specific fashion, due to enzyme chirality’s, to form an
enzyme–substrate complex (E-S*) as follows (Holum,
1983).