Muscle ischemia also has been shown to produce
substantial metabolic stress, and potentially produces an
additive hypertrophic effect when combined with glycolytic
training (136,182). The stress-induced mechanisms theorized
to mediate the hypertophic response include alterations in
hormonal milieu, cell swelling, free-radical production, and
increased activity of growth-oriented transcription factors
(50,51,171). It also has been hypothesized that a greater acidic
environment promoted by glycolytic training may lead
to increased fiber degradation and greater stimulation of
sympathetic nerve activity, thereby mediating
Muscle ischemia also has been shown to produce
substantial metabolic stress, and potentially produces an
additive hypertrophic effect when combined with glycolytic
training (136,182). The stress-induced mechanisms theorized
to mediate the hypertophic response include alterations in
hormonal milieu, cell swelling, free-radical production, and
increased activity of growth-oriented transcription factors
(50,51,171). It also has been hypothesized that a greater acidic
environment promoted by glycolytic training may lead
to increased fiber degradation and greater stimulation of
sympathetic nerve activity, thereby mediating
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