The current challenges to phage therapy studies are: (i) to demonstrate feasibility in vivo,(ii)to provide new insights at the in vitro
level, or (iii) to address the generality of principles that define the forefront of thefield.
The results of the present work, the first reporting the use of phages
to control bacterial infections in S.senegalensis juveniles, show that the
agent of furunculosis was efficiently inactivated by the new isolated
phage.In vitro studies indicated that some bacteria survived to the infection by the AS-A phage, probably due to the development of phage-resistance. However,in vivo studies showed that the presence of these
phage-resistant mutants did not negatively affect the control of the
infection