predominantly in Asian countries. The World Health Organization currently estimates
that there may be 50 million dengue infections worldwide
every year (http://www.who.int/mediacentre/factsheets/fs117/
en/index.html). To date, there is no effective vaccine or antiviral
drug available against these dengue diseases [1,2]. Thus, to overcome
this or any other future DV endemics, a detailed understanding
at the molecular level of DV replication and inhibition is crucial,
particularly for the design of novel dengue antivirus inhibitors.