The closest relatives of the Cyp360 subfamily in the
tree are the Cyp6 and Cyp9 subfamily members of insects
involved in endobiotic and xenobiotic metabolism and
detoxification. Similarly, the closest relatives of the two
Cyp361 subfamily members are the anemone CYP3-like
group, and the human CYP3A and CYP5A subfamily
members involved in detoxification and thromboxane A2
biosynthesis. In general, the CYP3 clan in insect species
has more CYPs than the Daphnia pulex CYP3 clan