Spirulina platensis can be cultivated in wastewater to improve water quality. The heavy metals contaminated in wastewater may be removed as well. The objective of this study was to some heavy metals; copper, mercury, and lead from Zarrouk’s Medium. Results showed that S. platensis rapidly accumulated heavy metals in the first phase of incubation and was slow down later. Based on Thai standard limitation of contaminants in wastewater, S. platensis still be alive. But, there was on growth of S.plantesis when copper contamination was over the standard limit (1 ppm). In contrast, the maximum levels of copper and lead contamination which allowed S. plantensis growth were 1 and 0.2 ppm, respectively