The antiplatelet effects of aspirn, clopidogrel and
dual combination were reported to have conflict
results in the CKD population. Recent studies have
shown that CKD is accompanied by a low platelet
inhibitory response to clopidogrel administration [17,
18]. However, Kaufman et al. found that clopidogrel
significantly inhibits ADP-induced platelet
aggregation even in subjects receiving chronic
maintenance hemodialysis [19]. Cuisset et al. also
found that no significant difference between patients
with or without CKD by two platelet function tests in
ACS population [20]. Furthermore, in the CURE trial,
clopidogrel was beneficial and safe in patients with
and without CKD [21]. In our study, CKD patients
received more clopidogrel tratment than non-CKD
patients. These atherosclerotic patients will be
followed up to see if there are potential beneficial
effects of clopidogrel in next fives years.