Currently, the incidence of multidrug resistant organisms
is increasing and compromising the treatment of a growing
number of infectious diseases. As a result, there is an urgent
need for developing new drugs which are effective against
current antibiotic resistant pathogens. Actinomycetes have
been proven as a potential source of bioactive compounds
and richest source of secondary metabolites[41]. Isolation of
antibacterial compounds from the freshwater environment is
in advance interest in recent times to isolate novel bioactive
actinomycetes. According to Sibanda et al., extracts from
three freshwater actinomycetes showed inhibition to Gram
negative bacterial strains compared to Gram positive
bacterial strains[42]. These recent studies motivated to isolate
antibiotic producing actinomycetes from fresh water and
sediments of Lake Tana