Three subjects carrying diagnoses of MCI may have progressed to AD by the time we began
training, despite a brief structured interview and administration of the DRS-2 at eligibility.
All of these subjects randomized to the intervention. None of the three subjects could make
it through the three stages of training curriculum for the MSS by the end of the 12 sessions,
and their results tended to lower adherence rates, ADL performance, and mood and
caregiver variables in our final results. These findings reflect a challenge to any MCI study,
and suggest individuals with more late stage MCI or transitioning into early AD may not
benefit as much from the current MSS training paradigm. By including more detailed
assessment of functional ability at the time of enrollment, future results should be able to
speak more to how individuals with earlier or more advanced MCI or early AD respond to
MSS training.