Effects on the fetal thyroid
There is a lack of correlation between fetal thyroid function and maternal dosage of antithyroid drugs (23, 41, 42). Decreased serum-FT4 in 36% of neonates is seen when the maternal serum-FT4 is in the lower two-thirds of the normal non-pregnant reference range. Maternal thyroid status is the most reliable marker, and in pregnant mothers with serum-FT4 levels in upper third of the normal range, serum-FT4 concentrations of over 90% of their neonates are within normal range (17, 23, 42). Overtreatment of pregnant ladies with antithyroid drugs resulting in decreasing maternal serum-FT4 is usually accompanied by fetal hypothyroidism.
Effects on the fetal thyroidThere is a lack of correlation between fetal thyroid function and maternal dosage of antithyroid drugs (23, 41, 42). Decreased serum-FT4 in 36% of neonates is seen when the maternal serum-FT4 is in the lower two-thirds of the normal non-pregnant reference range. Maternal thyroid status is the most reliable marker, and in pregnant mothers with serum-FT4 levels in upper third of the normal range, serum-FT4 concentrations of over 90% of their neonates are within normal range (17, 23, 42). Overtreatment of pregnant ladies with antithyroid drugs resulting in decreasing maternal serum-FT4 is usually accompanied by fetal hypothyroidism.
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