Taken together, the challenges faced by patients with inhibitors (Table1) combine to have a significant negative impact on well-being, as well as psychosocial functional
status. Patients are affected in both their personal and professional lives. Studies of health-related QoL have shown that significantly more patients with inhibitors had difficulties managing daily life challenges compared with those without inhibitors. Work-related challenges include medical absenteeism, concerns about insurance coverage,
and limitations for advancement and promotion. A greater proportion of patients with inhibitors may be unemployed or underemployed, or may receive disability incomecompared with patients without inhibitors and the general population.