STUDY LIMITATIONS
Our study is limited by its retrospective, single-center
design and relatively small number of patients with could not influence our decision to perform a workup for secondary hypertension, as evidenced by the fact that a similar proportion of TDM-adherent and -nonadherent patients underwent screening tests for PA. Despite the similar screening rate, a higher proportion of TDM-adherent vs -nonadherent patients had positive screening tests for PA (45% vs 19%, respectively), suggesting a true difference in PA prevalence. The cost of investigation for PA is likely to be underestimated because the screening test is assumed to be conducted only once per patient, while in the clinical setting, these tests are often conducted multiple times when the patients are seen by different physicians for persistently elevated BP.