The
model objective is to estimate the bioaccumulation potential of VOCs
and to provide insight in differences in magnitude of inhalation rate
constants and exhalation rate constants across species and chemicals.
For this purpose a one-compartment model is considered sufficient. If
exposure occurs only via inhalation of air, this bioaccumulation factor
can be estimated as the inhalation rate constant divided by the total
elimination rate (Eq. (2)). The equations for excretion via urine,
egestion with faeces and growth dilution have been developed by
Hendriks et al. (2001) and are provided in the Supporting Information.
The development of the inhalation and exhalation rate constants
is described in the next section.