Formaldehyde is known to be a primary skin and eye irritant in animals. This is based more on anecdotal evidence than robust animal studies. Formaldehyde causes skin irritation in humans.Transient and reversible sensory irritation of the eyes and respiratory tract has been observed in clinical studies and epidemiological surveys. Airborne concentrations associated with sensory irritation are above 0.3 to 0.5 ppm, eye irritation being the most sensitive endpoint. Moderate eye,
nose and throat irritation occurs at 2 to 3 ppm