Rheumatoid arthritis (RA) is an autoimmune disease particularly affecting elderly people which leads to massive bone destruction
with consequent inflammation, pain, and debility. Allopathic medicine can provide only symptomatic relief. However, Zingiber
officinale is a plant belonging to the Zingiberaceae family, which has traditionally been used for treatment of RA in alternative
medicines of many countries. Many of the phytochemical constituents of the rhizomes of this plant have therapeutic benefits
including amelioration of RA. This review attempts to list those phytochemical constituents with their reported mechanisms of
action. It is concluded that these phytochemicals can form the basis of discovery of new drugs, which not only can provide
symptomatic relief but also may provide total relief from RA by stopping RA-induced bone destruction. As the development of
RA is a complex process, further research should be continued towards elucidating the molecular details leading to RA and drugs
that can stop or reverse these processes by phytoconstituents of ginger.