There are several physical therapy interventions available for the management of patients with CTS. One of these techniques is neurodynamic technique, which is a form of manual therapy that directs force to neural structures through positioning and movement of multiple joints. 6 Neurodynamic interventions claim to improve pain and function in patients with neural symptoms, for example, cubital nerve syndrome.7 Some studies have shown that neurodynamic interventions exhibit promising results for decreasing pain in CTS8-10; however, a review focused on neural mobilization for CTS concluded that the evidence for the effects of nerve gliding neurodynamic exercises is not clear.11 The authors of this review concluded that the neurodynamic techniques may be effective in a specific population of subjects with CTS, particularly in those with lower hyperexcitability of the central nervous system.11 This hypothesis was partially supported by a study where central sensitization was not present in women with CTS who are likely to achieve a successful outcome with physical therapy including soft tissue mobilization and a passive nerve slider neurodynamic technique targeted to the median nerve.The purpose of this case series was to examine possible effects of a nerve slider neurodynamic intervention targeted to the median nerve on widespread pressure pain sensitivity in individuals with CTS. We hypothesized that the application of the neurodynamic intervention would increase pressure pain thresholds (PPTs) at both local symptomatic and distant pain-free area