The real meaning of the follicular route was not previously well accepted because the openings of hair follicles
occupy only about 0.1% of the total surface area of the skin. However, hair follicles provide a large space for easy transport
of vesicles into the skin, besides being an invagination of the epidermis extending deep into the dermis. This could provide a larger area for potential absorption and may influence the transdermal absorption of drugs