Patients with CRS were reassessed after 1 month’s therapy with nasal saline irrigation and 25 μg per nostril of intranasal fluticasone or equivalent administered twice daily.18 Acute exacerbations, which were observed in 18 patients, were treated with a 2-week course of amoxicillin-clavulanate (clarithromycin in 2 cases of penicillin allergy).26