Important questions remain to be addressed regarding
cognitive interventions in MCI. One question concerns
the characteristics of those sub-groups with MCI
who are most likely to benefit from the intervention. Another
question is to determine the limit after which intervention
is no longer appropriate in the evolution of the
disease as cognitive deficits accumulate in severity and
quantity. The present study focused on short-term symptomatic
improvement and another critical issue that is
worthy of investigation is the extent to which intervention
can delay the manifestation of the disease in those
individuals who will evolve to AD. Answers to these
questions will necessitate the use of much larger sample
sizes, as well as the follow-up of treated and non-treated
patients. The present data suggest that this is a worthy
endeavor.