You should not use this medicine if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have:
alcoholism, cirrhosis, or other liver disease;
a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells);
a bone marrow disorder; or
if you are breast-feeding a baby.
Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.
To make sure methotrexate is safe for you, tell your doctor if you have:
kidney disease;
a folate deficiency;
pneumonia or lung disease;
stomach ulcers;
any type of infection; or
if you are receiving radiation treatments.
FDA pregnancy category X. Methotrexate can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment.