For analysis of the data, statistical software (PASW statistics, version 17.0; IBM SPSS Statistics, Armonk, NY, USA) was used. Data for receptor mRNA expression and number of goblet cells were normally distributed (Kolmogorov– Smirnov test), and groups were compared by t-test. Data for scored histomorphological parameters were compared by nonparametric Mann–Whitney U-test between groups and by Friedman test and Wilcoxon test between different localizations in the same animals. A P value